Study of the biological effect of phenol and some of its halogenated derivatives on bacterial respiration

Abstract

The aim of this work is to focus on phenol compound and some of its halogenated derivatives. These compounds are of great importance because of their high biological activity. Thus, it is necessary to search the relationship that explains the different biological behaviour on the C. violaceum respiration. To monitor the energy emitted during the respiration process of this bacteria, a flow microalorimetery was used. In order to obtain the physiochemical properties of these compounds, quantum calculations have been employed. Finally, the chemometric analyses have been used to find the relationship between physiochemical properties and biological activity. This research ends up with that the biological activity of these compounds depends mainly on the physiochemical properties, and any change occurs in this properties leads to a change in their biological activity. It was also observed that penta-bromophenol compound was far from the pentachlorophenol compound; whereas this compound (penta-bromophenol) was closer to the monochlorophenol compound in terms of the physiochemical properties. This result makes the researcher expect that this compound would have a very low biological activity, in case it is exposed to the same bacteria.