Synthesis of Some Benzyl Oxime Ethers

A reaction between hydroxylamine hydrochloride with five aldehydes and ketones under basic conditions produced oximes 1 – 5 in moderate to excellent yields. These five resulting oximes were characterized using spectroscopic techniques, including IR, 1HNMR and mass spectrometry. The obtained analytical data confirmed the structures of all five oximes. The 1HNMR of the acetaldehyde oxime 1 showed the formation of two geometrical isomers in a ratio of (1:1) These oximes were then subjected into a reaction with the benzyl chloride mild basic conditions by which the corresponding benzyl oxime ethers 6 – 10 were obtained in moderate to excellent yields ranging from 37% to 95%.