The therapeutic role of vitamin C against acrylamide-induced hepatorenal toxicity

This study aims to investigate the therapeutic role of vitamin C against acrylamideinduced
hepatorenal toxicity in male and female rats. Forty -two male and female albino rats were divided into three groups. Acrylamide was administered daily in drinking water as the above and vitamin C was given daily in drinking water for 4 weeks. Dissolved 5000 mg of effervescent vitamin C tablets produced by the Chemical
Industries Development Company (CID) in 500 ml of water and each 1 ml of water contains 2 mg of vitamin C and given 20 ml of the solution for the male cage and 30 ml for the female cage There was a significant decrease of ALT activity within
the control group (50.50±11.03 U/L) where in rats drinking acrylamide there was increase (55.00±8.59 U/L) acrylamide and treated with vitamin C, were the least activity(45.92±9.12 U/L) there are no differences between male and female in ALT activity in the control group,