Substantial microleakage at the interface between the core and the dentin substrate may occur. A tight and impervious bond between the Dentin and the restorative material is critical for the longevity of Core restorations. This study evaluated the microleakage of reinforced core build up materials, two composite resins, two glass ionomer cements and amalgam treated with dentin bonding agents or with conditioner. The results indicated that dentin bonding agent is most effective in reducing microleakage at tooth/core interface of reinforced composite cores and amalgam core, while reinforced glass ionomer cement cores with conditioners has no effect in reducing the microleakage.