The study was conducted on patients attending the dermatology clinics at Misurata hospital center during the period between April to August of 2018. One hundred and twenty (120) samples were collected to isolate and identify Candida albicans. Microscopic examination (light and scanning microscopy) was carried out to identify the morphology of the isolate, also different concentrations of alcoholic and aqueous garlic extracts (20%, 30% and 40%) were screened for their efficacy in inhibiting of vegetative growth of C. albicans. The. Positive fungal infection was found in 75 sample. The most common fungal pathogens, collected by swabs from the skin, scalp, mouth, vagina and nail clippings, were Candida species and other filaments fungal , with C.albicans being the predominant isolate (35%).The antifun-gal susceptibility testing showed that The most common fungal pathogens, were Candida species and other filaments fungal. C.albicans being the predomi-nant isolate (35%).The antifungal susceptibility testing showed that alcoholic garlic extracts had high efficacy inhibition growth of C. albicans, where the inhibition growth percentage was 97.5% at a concentration of 40mg/ml and without significant difference compared to the Nystatine, while- the high percentage of inhibition by aqueous extracts of garlic was 10.46% at a concentration of 20 mg/ml with a very high significant difference compared to the Nystatine. The antifungal effect of alco-hol extracts of garlic is better than the aqueous extract for C.albicans(p < 0.001). garlic extract has a significant antifungal effect towards C.albicans.