EXPRESSION OF EXTRACELLULAR MATRIX METALLOPROTEINASE INDUCER (EMMPRIN) AS A BIOMARKER IN ORAL SQUAMOUS CELL CARCINOMA (OSCC)

Ben amer A.M; Omer E M; Elsheikh S.M

doi:10.36602/mmsj/2021.n07.02

EXPRESSION OF EXTRACELLULAR MATRIX METALLOPROTEINASE INDUCER (EMMPRIN) AS A BIOMARKER IN ORAL SQUAMOUS CELL CARCINOMA (OSCC)

Authors

Ben amer A.M Demonstrator, Department of Oral Pathology, Faculty of Dentistry, misurata University
Omer E M Faculty of Dentistry, Alexandria University, Egypt
Elsheikh S.M Department of Oral Pathology, Faculty of Dentistry, Alexandria University Egypt

DOI:

https://doi.org/10.36602/mmsj/2021.n07.02

Keywords:

Oral squamous cell carcinoma, EMMPRIN

Abstract

EMMPRIN is a widely distributed cell surface glycoprotein that belongs to immunoglobulin (Ig) super family. It is
inducing the production of extracellular matrix metalloproteinase (MMP) enzymes and play important role in angiogenesis via stimulation of vascular endothelial growth factor (VEGF). The aim of the present work is to evaluate and
asses the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in oral squamous cell carcinomas
and to compare the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in different types of
oral squamous cell carcinomas. Thirty diagnosed cases of Oral squamous cell carcinoma (OSCC) were selected and
immunohistochemistry was performed for EMMPRIN. All cases showed positive EMMPRIN expression with different intensity. This study concluded that the elevated expression of EMMPRIN levels correlate with tumor proliferation, angiogenesis, metastasis and invasion.

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Published

05-10-2025

How to Cite

Ben amer A.M, Omer E M, Elsheikh S.M. EXPRESSION OF EXTRACELLULAR MATRIX METALLOPROTEINASE INDUCER (EMMPRIN) AS A BIOMARKER IN ORAL SQUAMOUS CELL CARCINOMA (OSCC). mmsj [Internet]. 2025 Oct. 5 [cited 2026 Apr. 17];4(2):7-12. Available from: https://journals.misuratau.edu.ly/mmsj/ojs/index.php/mmsj/article/view/95

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Issue

Vol. 4 No. 2 (2021)

Section

Original article

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