THE E-CADHERIN ADHESION MOLECULE STUDY IN LIBYAN PATIENTS WITH COLORECTAL CANCER

Hebaalla M.Alfannas; Mussa A.Alragig; Mohamed A.Elfagieh; Abdul hakim Elbakush; Fathi B. Abdalla; Rabia Alkikle

doi:10.36602/mmsj/2017.n06.09

Authors

Hebaalla M.Alfannas Department of surgery, Misurata cancer center, Misurata, Libya
Mussa A.Alragig Department of surgery, Misurata cancer center, Misurata, Libya
Mohamed A.Elfagieh Department of surgery, Misurata cancer center, Misurata, Libya
Abdul hakim Elbakush Department of pathology,Al asmarya Islamic university, Zliten, Libya
Fathi B. Abdalla Department of pathology, African oncologyinstitute, Sabratha, Libya
Rabia Alkikle Department of pathology, Misurata cancer center, Misurata, Libya

DOI:

https://doi.org/10.36602/mmsj/2017.n06.09

Keywords:

Colorectal Cancer, E-Cadherin, Metastasis, Recurrence Rate

Abstract

Colorectal cancer (CRC) is a major cause of cancer-related death worldwide. As tumor-node-metastasis staging system still remains the gold standard assessment of CRC patient`s prognosis, but it is no longer sufficient. E-cadherin
is one of the most important adhesive molecules involved in colorectal tumor growth, cell proliferation and progression. The aim of study is to investigate E-cadherin expression and evaluate its prognostic value in Libyan colorectal
cancer cases. Sixty Libyan patients with colorectal cancer diagnosed between 2004-2012 in Misurata cancer center
and Zliten central hospital were retrospectively studied. E-cadherin expression was detected by immunohistochemical staining of paraffin blocks using the automatic system, focused on the membranous staining pattern and two categories were applied, negative or positive. E-cadherin expression was significantly correlate with the tumor location
where the colon tumor expresses E-cadherin more than in the rectal ones. Lymph nodes metastasis is more frequently detected in tumors that showed loss of E-cadherin expression. There is significant association in this current study
between loss of E-cadherin expression and increase recurrence rate and distant metastases of the tumor. Clinical
variables as age, gender or tumor grade showed no significant association with E-cadherin expression. Investigation
of E-cadherin expression and distribution in colorectal tumors is extremely valuable for the prediction of outcomes
and rate of recurrence. These data may help to improve decisions concerning the therapy and management of colorectal cancer patients.