LANGERHANS CELL HISTIOCYTOSIS SINGLE SYSTEM MULTIFOCAL BONE INVOLVEMENT

Abstract

Langerhans cell histiocytosis is a rare disease with abnormal accumulations of
Langerhans cells in different body organs. The skeletal system is a commonly the
affected site in pediatric populations, and treatment modalities are varied according to
the affected sites and the extent of the disease. We present the clinical details of a 12-
year-old girl patient diagnosed with single-system multifocal skeletal involvement (SSLCH). The scans of her spine revealed a full collapse fracture of the seventh thoracic
vertebral body, along with other lytic lesions affecting the vertebrae at levels D2, D5,
and L1. The patient had chemotherapeutic treatment in accordance with the established
guidelines for Langerhans cell histiocytosis. The radiographic features alone may evoke
a higher level of suspicion for Langerhans cell histiocytosis (LCH), but they lack
sufficient diagnostic capacity on their own. Histopathological examinations are
necessary to definitively establish or rule out a diagnosis of Langerhans cell
histiocytosis (LCH). Prompt medical intervention is necessary in order to halt the
advancement of the disease and mitigate the need for more intrusive therapeutic
measures.